Pleiotrophin and metabolic disorders: insights into its role in metabolism

Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of central nervous system, however few studies focus on its role in peripheral organs. The main aim this review to summarize state art what known up date about pleiotrophin and implications metabolic In summary, promotes proliferation preadipocytes, pancreatic β cells, as well cells during mammary gland development. Moreover, important structural integrity liver neuromuscular junction skeletal muscle. From point view, plays key maintenance glucose lipid whole-body insulin homeostasis favors oxidative metabolism All all, proposes druggable target prevent from development insulin-resistance-related pathologies.